Hi Blaine,
If the CMS allow to modify title of the page, meta description, page content, anchor text, url structure, etc. then there nothing to worry about.
As long as you can set those as you wish and that the source code is clean and readable by search engines, then it there shouldn't be any problem.
Search engine spiders doesn't care what CMS you use, they look at the source code of the page and gather the information they need.
So, as long as the pages can be parsed by spiders and that you can modify the important stuff on it, it can be optimized.
Best regards,
Guillaume Voyer.