If you are mostly targeting Netherlands than buy a .NL extension not DE. Secure both if expanding.
I would prefer with the amlaut if it is a German site being targeted in Germany, so it is better because people typing into google.de will be using the amlaut and this is the proper spelling for this word. That is assuming you can get a domain name with amlaut characters registered.
Will it make a big difference in rankings, probably not much so if it's a matter of getting a available domain name for cheap or paying a lot of money to purchase it off of a seller I would go with the cheaper route.
You can also look for a alternative domain name that has schädlinge with the amlaut in it and is available.
You will of course be using the amlaut in the site content and can use it in directory and filenames as well so you're still showing Google and the user what they want to see.
Use the word with the amlaut in the title tag and the meta description.