I would classify our site as large (www.covers.com), with our primary target being traffic within the US (about 70%) but I have a feeling we are limited by our IP being located within Canada. I have changed all the targeting to the US in WMT, but could undertake a project to virtually 'move' the site to a US IP, if there would be benefit. I have found articles coming down on both sides of the issue.
Thoughts?