I would say that it is more important to have a direct match (keyword) domain name with a .uk inclusion. If a .co.uk or .com isn't available then any other .uk domain in my opinion would be the best way forward.
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RE: For a UK business where there is no .co.uk or .com opportunity, is it better to have a .net address or would .uk.com be better? Or no difference...This company is UK focussed only.