I do, I run a pretty large wiki (2400 articles, over 1000 users) and I can definitely vouch for it. Out of the box it uses canonical tags as well (for redirect pages), knows which pages it should index and which it shouldn't (edit & login pages for instance are noindexed) and Google can handle an out of the box install pretty well.
If needed you can even use one of the meta plugins to optimize your descriptions, titles and noindex/nofollow certain pages or even namespaces. (I wrote the AdvancedMeta plugin, but there's plenty of others).