I have a feeling there is going to be a lot of diversified opinion in this thread, but here is my opinion.

First, to answer your direct question, I do think localized optimization in <title>is going to slightly affect your non-geographic rank. You've got 10oz of SEO Juice to split up amongst however many keywords you've got in your title, and pulling a geo-identifier into that is going to dilute the non-geo a bit. Maybe. Possibly. Probably.</p> <p><em style="background-color: initial;">That being said</em><span style="background-color: initial;">, you have to consider what keyword you're targeting, and whether or not they're triggering the x-pack in a SERP anyway. This speaks to question #2. If you want to rank nationally and locally, and who doesn't, consider your separate search verticals. If your target queries aren't triggering the x-pack, then take into account search volumes on those geo-specific terms.</span></p> <p>If you want to focus on local, non-map placements, I'd use the following <title> methodology:</p> <p><em>pagesubject city, stateabv | brandname</em></p> <p>e.g Oil Change Plymouth, MI | Midas</p> <p>Of course there could be a substantially more in-depth exploration of this topic, and I'm hoping one of my fellow inbound marketers will expand upon the subjects I didn't touch.</p></title>

No worries. Yes, the x-pack is the local listing that sometimes appear in a SERP. X because sometimes it's3, sometimes 7, and occasionally I think there can still be 10, but not sure there.

When doing keyword research I'd recommend pulling numbers both without and with the geographic identifier, phrase and exact match. Use Insights for Search for some good geographic data, too.