As of my experience in SEO first of all it's better to get the full list of backlinks that are associated to your website, whether they are do-follow or no-follow or any other type of link. Then analyze the domain they are connected to and check the relevancy of the domain with your website, on top of that you can segregate the domains having higher spam score and low DA, these domains are affecting your domain the most. Then after making a proper analysis from the data of your website's backlink you'll get a clear image of which links are harming your website and then disavow these links and domain from Google Search Console.
Hope this will help you.
