I'll give you a direct answer. No. Directory submission sites are no longer relevant due to search engines, and they are seen by Google as nothing more than sites designed to sell links and pass PR.
Smart link builders stopped this activity years ago. There are only a small handful of directory sites like yahoo that are worth submitting. 99% of them are not.
If you find a directory site that is in your niche and nofollows your link then it might make sense to get listed as a possible traffic driver.
It takes a lot to get your site removed from Google index, the easiest way is to be hacked then your site gets banned until you remove those links.
What would most likely happen with directory submissions is that the keywords you are targeting get suppressed in the rankings, you go from page one to page 50 for example and your traffic drops. Google emilas you a letter in WMT saying they detected unnatural link building and then you spend all sorts of time trying to get your links removed and disavowing and resubmitting for reconsideration.
Directory sites are dead, if you're going to do link building it needs to be one offs to individual sites who have never sold links, not on sites who's sole business is to sell links.