I think nobody will blame me if I tell you YES, because until now it is not proven fact that the appearance of your keywords in meta description will make an impact on your rankings. However I will recommend two things:
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If you use any type of CMS (Joomla or Werdpress) to build your website then you can download the plugin which generates the meta description automaticaly.
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Still it's better if you will include the targeted keywords from page to meta description, and even if you check SeoMoz on-page optimization, those guys are recommend to do this.
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Remember that attractive and interesting Meta Description might highlight you among your competitors and bring you additional traffic even if you are not TOP1.
Hope that it was clear.
I've just got a Pro membership on SeoMoz and I am full of questions.